There are many varieties and quantities of tablet presses. Tablet presses have been used in the domestic pharmaceutical production industry for a long time.
The output of tablet presses is large and the export is early. According to the survey, there are dozens of manufacturers in the tablet press industry in China, with an annual output of several thousand units. The tablet press can press round tablets, lettering, and special-shaped tablets.
The tablet press is also relatively simple to operate. In recent years, the tablet press industry has begun to pay attention to the quality of tablets and the concept of winning by quality. There are many pharmaceutical factories and there are many types of tablets. The tablet press developed by the tablet press manufacturer has the characteristics of simple operation and simple cleaning.
Tablet machine tableting principle: dose control. Various tablets have different dosage requirements, and large dosage adjustments are achieved by selecting dies with different punch diameters. After the die size is selected, the small dose adjustment is to adjust the depth of the lower punch extending into the middle die hole, thereby changing the actual length of the middle die hole after back sealing, so as to achieve the purpose of adjusting the die hole and the filling volume of the Chinese medicine.
Therefore, there should be a mechanism for adjusting the original position of the lower punch in the die hole on the tablet press to meet the dosage adjustment requirements.
Tablet thickness and compaction control. The dosage of the drug is determined according to the prescription and pharmacopoeia and cannot be changed. For storage and transportation, preservation and disintegration time limit requirements, the pressure of the dose is also required during tableting, which will also affect the actual thickness and appearance of the tablet. Pressure regulation during tableting is essential. This is achieved by adjusting the downward amount of the punch in the die hole.
Some tablet presses not only have the upward and downward movements of the upper and lower punches during the tableting process, but also have the upward movements of the lower punches, and the relative movement of the upper and lower punches completes the tableting process. However, the pressure regulation is mostly realized by the mechanism of adjusting the upward and downward flow to realize the pressure regulation and control.
Causes of sticking and punching of tablet press: Sticking and punching refers to the fact that the fine powder on the surface of the tablet is adhered by the punch and the die during tableting, resulting in not smooth, uneven and dented surfaces, and the lettering punch is more prone to sticking and punching.
Damaged or degraded surface finish of the punch, there may also be anti-rust oil or lubricating oil, the surface of the new die is rough or the lettering is too deep and angular. The punch can be wiped clean, the substandard punch can be exchanged, or the surface of the lettering punch can be rubbed with a small amount of liquid paraffin to lubricate the surface. In addition, if the sticking is caused by mechanical heat, the cause should be checked and the equipment should be overhauled.
The design of engraved and punched characters is unreasonable. Replace the punch or change the character design accordingly. Excessive water content of the particles or uneven drying and wetness of the particles causes sticking. Solution: Control the moisture content of the particles at about 2% to 3%, and strengthen the dry particle inspection.
Insufficient amount of lubricant or improper selection, too much fine powder. The amount of lubricant should be appropriately increased or new lubricant should be replaced to remove excessive fine powder.
The fineness of raw and auxiliary materials varies greatly, resulting in uneven mixing or improper mixing time. Solution: crush and sieve the raw and auxiliary materials, so that the fineness of the tablet press can meet the quality requirements of the variety, and at the same time master and control the mixing time.
The above is the industry sharing about tablet presses, I hope everyone can like it.