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Key Takeaway Capsule fill weight variation is rarely solved reliably by changing one machine setting at random. First confirm that the variation is real and separate shell-weight variation from net fill-weight variation; then check powder flow, bulk-density changes, moisture, powder-bed consistency, machine speed, and the dosing mechanism in a controlled sequence. The most useful evidence is a time-ordered weight record linked to material properties and actual machine settings. Change only one factor at a time under an approved procedure so that an apparent improvement can ... Read More