Recently, a user said that its wet granulation mechanism of particles, in the drying of the whole granule, sealed after placed in the dryer, but after a period of time found the lump, press can be restored.The user wants to know what causes this phenomenon?How to solve it?
To this, the personage inside course of study listed four reasons, including sealing problems come into contact with air oxidation dryer granule infusion of higher temperature instability, etc., and gives the corresponding solution.
If there are a few of water vapor into the dryer, easy to make the water vapor and particle surface adhesion, happen agglomerate in this case, the user should do is make sure the dryer sealing, prevent water vapor into the dryer in the industry, said the user will need to know when choosing dryer equipment sealing brand is on the other hand, when the choice of selection is also key to take a look at their work, the key is, the smoothness of mouth can circle around, feel the friction condition, but the need to experience;In the operation, the lid can't just buckle, to rotate, and push the industry around said
The oxidation problem
When particles come into contact with oxygen in the air, they oxidize slowly, changing the properties of the material on their surfaces and forming clumps.
It is reported that some granule, such as Chinese traditional medicine granule, is easy to absorb water and harden in the storage process, affecting the quality. In addition, the granule after moisture absorption is more likely to be oxidized, hydrolyzed and mildewed, and appearance changes and effective components decrease.The industry suggests that, in view of this kind of situation, we can start from the early production and choose the auxiliary materials with less moisture absorption or change the proportion of the auxiliary materials. In addition, we can strictly control the water in the production process for the granule of traditional Chinese medicine, and use the auxiliary materials with less moisture absorption as far as possible to optimize the granulation method.
The dryer is too hot
If the dryer is too hot, it will melt.The personage inside course of study points out, pellet granule is not crystal, do not have fixed melting boiling point, easy to melt below the circumstance with too high temperature, produce caking phenomenon, be like white sugar or brown sugar same.
To this, the industry suggests that, if it is environmental impact, you can put the dryer in a cool dry place, avoid the temperature is too high or humidity in the place.
In addition, if it is the dryer equipment itself, need to carry out the corresponding treatment.According to the introduction, the steel tube between the dryer and the air compressor is used for heat dissipation, the length of the steel tube determines the temperature of the dryer.Users in the choice of dryer, in addition to pay attention to quality, sealing, but also need to check whether the system is normal, in addition, regular maintenance of dryer is also crucial.In the process of daily use, should develop a good inspection habit.
The instability of granule itself
It is understood that the wet granulation system refers to the drug powder or thick paste and auxiliary materials placed in the appropriate container to mix evenly, adding wetting agent into a "hand pinch into a group, pressure is loose" soft material, and then through the way of extrusion screen (plate) to make uniform particles.After wet granule is dry, can have partial caking, adhesion.
It is recommended that the dry particles should be sifted again after cooling to make the particles uniform.In addition, in the processing of raw materials, auxiliary materials can be selected to increase the stability of granules.
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