The raw materials and excipients used in the automatic high-speed tablet press must be crushed, sieved or dried before mixing. General medicines are more suitable for passing through 80~100 mesh sieves. For toxic drugs, valuable drugs and colored raw materials, it is still necessary to make fine powder and pass through a 120-mesh or larger sieve.
Because fine powders are easy to mix. When mixing, it must be mixed with the main and auxiliary materials according to the equal increment method. A small amount of the main drug can also be dissolved in a suitable solvent, absorbed with a small amount of thixotropic agent, then mixed in equal increments and screened repeatedly.
In short, it should be completely mixed. Cellulose acetate agents or liquid extracts contained in prescriptions can be concentrated into a syrup and then mixed with other ingredients as a binder. After the granules are dry, any volatile drugs or essential oils should be added. Avoid heat loss. Batch production can be combined with a mixer or airflow mixer.
The fully automatic high-speed tablet press should be installed in a well-lit, warm, dry and clean place. This situation has a lot to do with the success or failure of tablet compression.
If the area is wet, for hygroscopic drugs, you have to wait until a dry climate to press the sheet, or you have to install humidity control equipment. Relative humidity usually does not exceed 70%. If possible, a mixer and granulator can be installed in one room, or an oven is included, but the tablet press should be installed in another room.
The location of the fully automatic high-speed tablet press should allow workers to see each machine clearly in principle. Paint equipment should be installed in another room. After the machine is installed, it should be rotated slowly by hand, carefully observing the parts for proper functioning and flexibility.
Do not open the motor backwards to avoid damage due to improper installation. When installing for the first time, you should pay attention to lubricating the rotating parts of the machine to make the operation flexible; after using it for a period of time, please pay attention to its use at any time.
The washing machine should occupy an important position. The buildup of fines is often difficult and must be removed from time to time. The rotary press is equipped with cleaning equipment to reduce the accumulation of fines. However, due to the complexity of the structure, some moving parts are often hidden, so special attention should be paid to them.
It is a good practice to disassemble and assemble all machines regularly, for example once a week. The mold ring is in direct contact with the drug, so it is most susceptible to infection and should be cleaned once a day. Mold tables should be cleaned at all times to remove greasy substances. Flushing is the most likely to accumulate fine electrodes and must therefore be taken into consideration.
Application of tablet press machine