After the freeze-dried product is vacuum freeze-dried in the freeze dryer, the product needs to be taken out of the box and sealed for storage. Since the freeze dryer is still in a vacuum state when it is finished drying, the product must be put in air before opening the warehouse door to take out the product. The air put in should be sterile dry air.
Due to the different storage requirements of the product, the handling of the freeze-dried product out of the warehouse also varies. Some products only need to be placed in sterile dry air and sealed out of the box for storage. Some products need to be filled with nitrogen for storage.
Put nitrogen into the warehouse when they leave the warehouse, and then fill with nitrogen and seal them after leaving the warehouse. Some products need to be stored in vacuum, and they need to be vacuum-sealed again after they are out of the warehouse.
Once the freeze-dried product is exposed to the air, it is easy to absorb moisture in the air and deliquescence, especially in humid weather. Therefore, the freeze-dried products should be sealed quickly after they are out of the warehouse.
If the sealing time is too long due to the large quantity, appropriate measures should be taken or the products should be out of the warehouse in batches.
Because the freeze-dried product is dried in a vacuum environment, it is not affected by oxygen. When air is put into the warehouse, the oxygen in the air will immediately penetrate into the gap of the dried product, and some active ingredients will quickly combine with oxygen.
The product has an effect, resulting in irreversible oxidation. If an inert gas, such as nitrogen, is put into the warehouse, oxygen will not easily penetrate into the gap of the product, and the degree of oxidation of the product will be reduced.
The method of corking in the box can also solve the problems of moisture and oxidation, but this method requires the use of a freeze dryer equipped with a stopper device, as well as a matching freeze-drying bottle and stopper.
Application of freeze dryer Machine
Freeze dryers are widely used in medical, pharmaceutical, biological research, chemical, food and other fields.