The semi-automatic capsule filling machine has fast filling speed and small size difference. The machine integrates powder filled capsule shell, capsule cap and capsule package, which is compact and convenient. It is suitable for small and medium-sized pharmaceutical factories, health product factories, hospitals and clinics to produce in small and medium-sized batches. If 2-3 sets are used at the same time, it can also be suitable for mass production.
With the improvement of preparation technology, the preparation of hard capsules has gradually changed from simple manual preparation to mechanized preparation, followed by the problem of the limit of difference in capsule loading. By analyzing and testing the factors that affect the difference of the capsule loading, the problem of the difference of the capsule loading has been solved. The quality of empty capsules and the quality of capsules directly affect the difference in the amount of capsules.
The choice of drugs for empty capsules. There are eight different sizes of empty capsules. There are four types of capsules 0, 1, 2, and 3 commonly used in preparations. Because the dosage, density, crystalline state, particle size, and excipients of each drug are different, only after the large amount of zui is manually loaded for various drugs can the appropriate empty capsules be selected, To obtain a small difference in loading capacity.
Secondly, we should select capsules with specification and size, and their size, specification and other quality standards should meet the quality standards for hollow capsules stipulated by the Ministry of Health in 1985. Secondly, the empty capsules should be stored in an environment with a temperature of 18-28 degrees and a humidity of 30% - 45%, and sealed.
Because empty capsules contain 12% - 15% water, improperly stored capsules will absorb water or dehydrate, resulting in changes in capsule diameter and shape, and mechanical filling is impossible.
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